Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb
货号：
3233S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3233S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb detects endogenous levels of Gab1 only when phosphorylated at Tyr627. The antibody may cross-react with phosphorylated Gab2 or Gab3, or with activated receptor tyrosine kinases (RTKs). |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane where it is phosphorylated and functions as a scaffold (1-4). Multiple tyrosine phosphorylation sites of Gab1 protein have been identified (5). Phosphorylation of Tyr472 regulates its binding to p85 PI3 kinase (6,7). Phosphorylation of Gab1 at Tyr307, Tyr373 and Tyr407 modulates its association to PLCγ (8). Phosphorylation of Tyr627 and Tyr659 is required for Gab1 binding to and activation of the protein tyrosine phosphatase SHP2 (6,9). |
| 存放说明 | -20C |
| 计算分子量 | 110 |
参考图片Western blot analysis of cell extracts from T47D cells, untreated or stimulated with heregulin, using Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb (upper) or Gab1 Antibody #3232 (lower).Western blot 检测分析T47D细胞提取物，未处理的和heregulin刺激的；使用的抗体是 Phospho-Gab1 (Tyr627) (C32H2) Rabbit mAb（上图）和Gab1 Antibody #3232 （下图）。 |
