Phospho-IRF-7 (Ser477) (D7E1W) Rabbit mAb
货号：
12390S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 12390S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-IRF-7 (Ser477) (D7E1W) Rabbit mAb recognizes endogenous levels of IRF-7 protein only when phosphorylated at Ser477. This antibody can also detect IRF-7 when dually phosphorylated at Ser477 and Ser479. This antibody may cross-react with proteins of unknown origin between 100 and 150 kDa. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3γ/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2). |
| 存放说明 | -20C |
| 计算分子量 | 65 |
参考图片Western blot analysis of extracts from HT-29 cells, untreated or treated with Human Interferon-α1 (hIFN-α1) #8927 (10 ng/ml, overnight) followed by transfection with poly(I:C) (2.5 μg/ml, 7 hr), as indicated, using Phospho-IRF-7 (Ser477) (D7E1W) Rabbit mAb (upper), IRF-7 Antibody #4920 (middle), or β-Actin (D6A8) Rabbit mAb #8457 (lower).Western blot分析HT-29细胞的细胞提取物，在转染了poly(I:C) (2.5 μg/ml, 7 小时)后，未处理或Human Interferon-α1 (hIFN-α1) #8927 (10 ng/ml, 过夜)处理，使用抗体是Phospho-IRF-7 (Ser477) (D7E1W) Rabbit mAb (上图), IRF-7 Antibody #4920 (中图), 或 β-Actin (D6A8) Rabbit mAb #8457 (下图)。 |
