Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb
货号：
8053S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 8053S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb recognizes endogenous levels of JunB protein when phosphorylated at Thr102 and/or Thr104. The antibody does not detect non-phosphorylated JunB protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | JunB is a basic region, leucine zipper (bZIP) transcription factor belonging to the Jun family that includes c-Jun and JunD. Jun family members homodimerize or heterodimerize with Fos and ATF proteins to form a functional transcription factor AP-1 (activator protein 1), whose activity is regulated by a variety of physiological and pathological stimuli such as growth factors, infections, and stress signals (1-4). While JunB sometimes antagonizes c-Jun transcriptional activity, it may functionally substitute for c-Jun during development in mice (5-7). JunB regulates hematopoietic stem cell number and plays an important role in the pathogenesis of chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 43 |
参考图片Western blot analysis of extracts from 293T cells treated with Anisomycin (25 ug/ml) for the time indicated, with or without pretreatment with JNK inhibitor SP600125 (40 min, 50 uM), using Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb (upper) or JunB (C37F9) Rabbit mAb #3753 (lower). |
