Phospho-LKB1 (Ser428) (C67A3) Rabbit mAb
货号：
3482S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3482S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-LKB1 (Ser428) (C67A3) Rabbit mAb detects endogenous levels of LKB1 when phosphorylated at Ser428. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases (1,2). A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases (3). AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations (4). LKB1 appears to be phosphorylated in cells at several sites,
including human LKB1 at Ser31/325/428 and Thr189/336/363 (5).
Mutation in the corresponding LKB1 gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet (6). A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues (7). |
| 存放说明 | -20C |
| 计算分子量 | 54 |
参考图片Western blot analysis of extracts from various cell lines, untreated or treated with TPA #9905 and UV, using Phospho-LKB1 (Ser428) (C67A3) Rabbit mAb (upper) and LKB1 (D60C5) Rabbit mAb #3047 (lower). Wetern blot检测多种细胞提取物，细胞未处理或用TPA #9905 和UV处理，所用抗体为Phospho-LKB1 (Ser428) (C67A3) Rabbit mAb兔单抗 (上)和 LKB1 (D60C5) Rabbit mAb 兔单抗#3047 (下)。 |
