Phospho-MOB1 (Thr12) (D2E3) Rabbit mAb
货号：
8843S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 8843S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | MOB1 was first identified in yeast as a protein that binds to Mps with essential roles in the completion of mitosis and the maintenance of ploidy (1). Its Drosophila and mammalian homologs, Mats and MOB1, respectively, are involved in the Hippo signaling tumor suppressor pathway, which plays a critical role in organ size regulation and has been implicated in cancer development (2-5). There are two MOB1 proteins in humans, MOB1α and MOB1β, that are encoded by two different genes but have 96.3% identity (6). Both forms bind to members of the nuclear Dbf2-related (NDR) kinases, such as LATS1 and 2 and NDR1 and 2, thereby stimulating kinase activity (7-9). This binding is promoted by the phosphorylation of MOB1 at several threonine residues by MST1 and/or MST2 (5,10). |
| 存放说明 | -20C |
| 计算分子量 | 24 |
参考图片Western blot analysis of extracts from MCF7 cells, untreated or H2O2-treated (2.5 mM, 30 min), using Phospho-MOB1 (Thr12) (D2E3) Rabbit mAb (upper) and MOB1 Antibody #3863 (lower). |
Western blot analysis of extracts from Ramos cells, untreated or λ phosphatase-treated, using Phospho-MOB1 (Thr12) (D2E3) Rabbit mAb (upper) and MOB1 Antibody #3863 (lower). |
