Phospho-NF-κB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)【科瑞奥博】

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Phospho-NF-κB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)

货号： 4808S 基本售价： 3980.0 元规格： -

产品信息

概述
货号	4808S
反应种属	Human
来源宿主	Rabbit
应用	IHC-P
目标/特异性	Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb detects endogenous levels of p105NF-kappaB only when phosphorylated at serine 933.
使用方法	IHC-P(1:150)

性能
供应商	CST
背景	Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins (3-5). NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression (6-8). NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus (9-11).
存放说明	-20C
计算分子量	105

参考图片

Immunohistochemical analysis of paraffin-embedded human colon carcinoma, showing cytoplasmic localization, using Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific).免疫组织化学染色分析石蜡包埋人结肠癌组织，图片所示为细胞质的定位。所用抗体为Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)。

Immunohistochemical analysis of paraffin-embedded human lung carcinoma, using Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific).免疫组织化学染色分析石蜡包埋人肺癌组织，所用抗体为Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)。

Immunohistochemical analysis of paraffin-embedded human colon carcinoma untreated (left) or lambda-phosphatase-treated (right), using Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific).免疫组织化学染色分析石蜡包埋未经处理(左图)和经lambda磷酸酶处理(右图)的人结肠癌组织，所用抗体为Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)。

Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific) in the presence of control peptide (left) or Phospho-NF-kappaB p105 (Ser933) Blocking Peptide #1021 (right).免疫组织化学染色分析石蜡包埋人乳腺癌组织。在对照多肽(左图)或Phospho-NF-kappaB p105 (Ser933) 封闭多肽 #1021 (右图)存在下所用抗体为Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)。