Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
货号：
9356S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9356S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 目标/特异性 | Phospho-Stat5 (Tyr694) (14H2) Mouse mAb detects endogenous levels of Stat5a only when phosphorylated at Tyr694 and Stat5b when phosphorylated at Tyr699. It does not cross-react with the corresponding phospho-tyrosines of other Stat proteins. |
| 使用方法 | WB(1:1000)
IP (1:200) |
性能| 供应商 | CST |
| 背景 | Stat5 is activated in response to a wide variety of ligands including IL-2, GM-CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation (1,2). This phosphorylation is mediated by Src upon erythropoietin stimulation (3). Stat5 is constitutively active in some leukemic cell types (4). Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility (5). Stat5a and Stat5b are independently regulated and activated in various cell types. For instance, interferon treatment predominantly activates Stat5a in U-937 cells and Stat5b in HeLa cells (6). |
| 存放说明 | -20C |
| 计算分子量 | 90 |
参考图片Western blot analysis of extracts from K562 and TF-1 cells, untreated, STI571-treated or GM-CSF-treated as indicated, using Phospho-Stat5 (Tyr694) (14H2) Mouse mAb (upper) or Stat5 Antibody (lower).Western免疫印迹。用Phospho-Stat5 (Tyr694) (14H2) Mouse mAb (上图) 或者 Stat5 Antibody (下图)抗体研究未经处理和经过STI571或GM-CSF处理的K562 和 TF-1细胞的细胞提取液。 |
