Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb【科瑞奥博】

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Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb

货号： 23706S 基本售价： 3980.0 元规格： -

产品信息

概述
货号	23706S
同种亚型	Rabbit IgG
反应种属	Human/Mouse/Rat
来源宿主	Rabbit IgG
应用	W IP IF-F
目标/特异性	Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb recognizes endogenous levels of α-Synuclein protein only when phosphorylated at Ser129. Specificity of nuclear staining is unclear but consistent with previous publications (4).
使用方法	WB(1:1000) IP (1:50) IF-F (1:1000)

性能
供应商	CST
灵敏度	Endogenous
背景	α-Synuclein is a protein of 140-amino acids expressed abundantly in the brain. α-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Research studies have shown that mutations of the α-synuclein gene are linked to Parkinsons disease (1).
存放说明	-20C
计算分子量	18
参考文献	1 . Goldberg, M.S. and Lansbury Jr., P.T. (2000) Nat. Cell Biol. 2, 115-119. 2 . Oueslati, A. et al. (2010) Prog Brain Res 183, 115-45. 3 . Credle, J.J. et al. (2015) Cell Death Differ 22, 838-51. 4 . Yu, S. et al. (2007) Neuroscience 145, 539-55.

参考图片

Confocal immunofluorescent analysis of mouse hippocampus using Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb (green). High-magnification showing punctate and sparse nuclear labeling (arrows). Specificity of nuclear staining is unclear (see Specificity/Sensitivity statement and supporting IF-F validation data). Blue pseudocolor = DRAQ5^® #4084 (fluorescent DNA dye).

Confocal immunofluorescent analysis of untreated (left) or λ phosphatase-treated (right) mouse hippocampus using Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb (upper), or α-Synuclein (D37A6) XP^® Rabbit mAb #4179 (lower) (green). Blue pseudocolor = DRAQ5^® #4084 (fluorescent DNA dye).

Confocal immunofluorescent analysis of mouse hippocampus using Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb (upper), or α-Synuclein (D37A6) XP^® Rabbit mAb #4179 (lower) (green), in the presence of Phospho-α-Synuclein (Ser129) peptide (middle) or Non-phospho-α-Synuclein (Ser129) peptide (right). Blue pseudocolor = DRAQ5^® #4084 (fluorescent DNA dye).

Western blot analysis of extracts from mouse brain, untreated (-) or λ phosphatase-treated (+), using Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb (upper) or α-Synuclein (D37A6) XP^® Rabbit mAb #4179 (lower).