Phospho-Stat6 (Tyr641) (C11A12) Rabbit mAb
货号：
9364S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9364S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Stat6 (Tyr641) (C11A12) Rabbit mAb detects endogenous levels of Stat6 only when phosphorylated at Tyr641. This antibody does not cross-react with the corresponding phospho-tyrosine residues of other Stat proteins. Cross-reactivity has been observed with receptor tyrosine kinases including phosphorylated PDGF receptor that can lead to inapproriate membrane staining. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Upon activation by Janus kinases, Stat6 translocates to the nucleus where it regulates cytokine-induced gene expression. Stat6 is activated via phosphorylation at Tyr641 and is required for responsiveness to IL-4 and IL-13 (1-4). In addition, Stat6 is activated by IFN-α in B cell lines, where it forms transcriptionally active complexes with Stat2 and p48 (5,6). Protein phosphatase 2A is also involved in regulation of IL-4-mediated Stat6 signaling (7). |
| 存放说明 | -20C |
| 计算分子量 | 100 |
参考图片Western blot analysis of extracts from HeLa and ACHN cells, untreated or treated with IL-4 (15 min), using Phospho-Stat6 (Tyr641) (C11A12) Rabbit mAb (upper) or Stat6 Antibody #9362 (lower).Western免疫印迹。Phospho-Stat6 (Tyr641) (C11A12) Rabbit mAb (上图) 或 Stat6 抗体 #9362 (下图)研究未经处理或经过IL-4 (15 min) 处理的HeLa 和 ACHN 细胞的细胞提取液。 |
