Phospho-Tau (Ser396) (PHF13) Mouse mAb
货号：
9632S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9632S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | Phospho-Tau (Ser396) (PHF13) Mouse mAb detects endogenous levels of Tau only when phosphorylated at serine 396. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimers disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimers disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). |
| 存放说明 | -20C |
| 计算分子量 | 50-80 |
参考图片Western blot analysis of extracts from mouse brain and CAD cells, using Phospho-Tau (Ser396) (PHF13) Mouse mAb. The phospho-specificity of the antibody was verified by peptide blocking using no peptide, phospho-peptide or nonphospho-peptide. Western blot分析小鼠大脑和CAD细胞，使用的抗体是Phospho-Tau (Ser396) (PHF13) Mouse mAb鼠单抗。抗体的磷酸化特异性通过使用对照、磷酸化多肽或非磷酸化多肽进行封闭实验而验证。 |
