| 货号 | 12885S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P |
| 目标/特异性 | Phospho-Tau (Thr181) (D9F4G) Rabbit mAb recognizes endogenous levels of Tau protein only when phosphorylated at Thr181. |
| 使用方法 | WB(1:1000) IP (1:50) IHC-P (1:100) |
| 供应商 | CST |
| 背景 | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by Erk, GSK-3, and CDK5 (1,2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimers disease; these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation at Ser396 by GSK-3 or CDK5 destabilizes microtubules. Furthermore, research studies have shown that inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).The cerebrospinal fluid concentration of Tau phosphorylated at Thr181 has been proposed to be a biomarker for the study of neurodegenerative disorders (4). |
| 存放说明 | -20C |
| 计算分子量 | 50-80 |
Immunohistochemical analysis of paraffin-embedded mouse colon, control (left) or λ phosphatase-treated (right), using Phospho-Tau (Thr181) (D9F4G) Rabbit mAb. 免疫组化分析石蜡包埋的小鼠结肠组织，对照组(左)或经过磷酸酶处理(右)，使用的抗体是Phospho-Tau (Thr181) (D9F4G) Rabbit mAb兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded human Alzheimers brain using Phospho-Tau (Thr181) (D9F4G) Rabbit mAb. 免疫组化分析石蜡包埋的人阿尔兹海默氏病人脑组织，使用的抗体是Phospho-Tau (Thr181) (D9F4G) Rabbit mAb兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded mouse brain using Phospho-Tau (Thr181) (D9F4G) Rabbit mAb. 免疫组化分析石蜡包埋的小鼠脑组织，使用的抗体是Phospho-Tau (Thr181) (D9F4G) Rabbit mAb兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Phospho-Tau (Thr181) (D9F4G) Rabbit mAb. 免疫组化分析石蜡包埋的人乳腺癌组织，使用的抗体是Phospho-Tau (Thr181) (D9F4G) Rabbit mAb兔单抗。 | |
