Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb
货号：
5638S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 5638S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Tyrosine kinase non-receptor 1 (TNK1) is related to the Ack1 (TNK2) non-receptor kinase that binds cdc42 and inhibits GTPase activity of this cell cycle regulator. TNK1 is broadly expressed in embryogenic tissues and leukemia cell lines, but is restricted to select adult tissues (1). TNK1 is a putative 72 kDa protein comprised of an N-terminal kinase domain, a central SH3 domain and a proline-rich tail. Interaction with PLCγ in vitro indicates a possible role in phospholipid signal transduction pathways (2). Though the exact mechanism is currently unclear, active TNK1 may play a role in regulating cell death by preventing TNF-α-induced NF-κB transactivation (3). |
| 存放说明 | -20C |
| 计算分子量 | 72 TNK1, 58 TNK1-C17orf61 |
参考图片Western blot analysis of extracts from L-540 cells, untreated or pre-incubated with either a site-specific phosphorylated peptide to block the signal or a site-specific non-phosphorylated peptide, using Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb. L-540 cells express a 58 kDa TNK1-C17orf61 fusion protein containing 466 amino acids from the amino terminus of TNK1 [Gu, T.L. et al. (2010) Leukemia].western blot方法检测细胞提取物：未处理和与能阻断信号传递的位点特异性磷酸化肽段、位点特异性非磷酸化肽段提前孵育的L-540细胞。使用的抗体是Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb。L-540细胞表达58 kDa TNK1-C17和f61融合蛋白，TNK1胺端包含466个氨基酸[Gu, T.L. et al. (2010) Leukemia]。 |
