| 货号 | 47061S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H |
| 来源宿主 | Rabbit IgG |
| 应用 | W IHC-P |
| 目标/特异性 | CELSR2 (D2M9H) XP® Rabbit mAb recognizes endogenous levels of total CELSR2 protein. |
| 使用方法 | WB(1:1000) IHC-P (1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | CELSR2 (cadherin EGF LAG seven-pass G-type receptor, also known as flamingo homolog 3 or epidermal growth factor-like protein 2) is a member of the flamingo subfamily of non-classical cadherins, part of the cadherin superfamily. CELSR2 is a 7-transmembrane helix receptor that contains nine cadherin-like domains, seven EGF-like repeats, and 2 laminin A G-type repeats (1). It shares structural characteristics of both an adhesion molecule and a G protein-coupled receptor, suggesting putatives roles in both cell-cell adhesion and juxtacrine signaling. Its function has been associated with dendrite morphogenesis (2), neural plate anterior-posterior pattern formation (3), and regulation of transcription via the Wnt signaling pathway (4). In a loss-of-function mouse model, Celsr2 deletion resulted in defects in the planar organization of ependymal cilia, leading to defective cerebrospinal fluid dynamics and hydrocephalus (5). In humans, SNPs in the CELSR2 gene cluster on chromosome 1 have been associated with enhanced risk of coronary artery disease (6). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 320 |
| 参考文献 | 1 . Vincent, J.B. et al. (2000) DNA Res 7, 233-5. 2 . Shima, Y. et al. (2004) Dev Cell 7, 205-16. 3 . Devenport, D. and Fuchs, E. (2008) Nat Cell Biol 10, 1257-68. 4 . Qu, Y. et al. (2014) Proc Natl Acad Sci U S A 111, E2996-3004. 5 . Tissir, F. et al. (2010) Nat Neurosci 13, 700-7. 6 . Zhou, Y.J. et al. (2015) Int J Clin Exp Pathol 8, 9543-51. |
Western blot analysis of extracts from MCF7, A549 and U-118 MG cells using CELSR2 (D2M9H) XP®Rabbit mAb (upper), and β-Actin (D6A8) Rabbit mAb #8457 (lower). | |
Immunohistochemical analysis of paraffin-embedded MCF7 (left) and U-118MG (right) cell pellets using CELSR2 (D2M9H) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human ovarian carcinoma using CELSR2 (D2M9H) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human skin using CELSR2 (D2M9H) XP® Rabbit mAb. |
