| 货号 | 62434S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IHC-P |
| 目标/特异性 | Napsin A (D5P6G) XP® Rabbit mAb recognizes endogenous levels of total napsin A protein. |
| 使用方法 | W IHC-P |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Napsin A is an aspartic proteinase that is expressed in normal lung and kidney (1). In the lung, napsin A is expressed by type II pneumocytes and alveolar macrophages, where it plays a role in processing surfactant protein B (2). Napsin A is expressed in lung adenocarcinomas, where it can be used to identify primary and metastatic lesions with greater sensitivity compared to TTF-1 (3,4). Napsin A expression has also been described in other types of cancer, such as kidney and thyroid cancer (5). |
| 存放说明 | -20C |
| 计算分子量 | 31 |
| 参考文献 | 1 . Tatnell, P.J. et al. (1998) FEBS Lett 441, 43-8. 2 . Schauer-Vukasinovic, V. et al. (1999) FEBS Lett 462, 135-9. 3 . Jagirdar, J. (2008) Arch Pathol Lab Med 132, 384-96. 4 . Turner, B.M. et al. (2012) Arch Pathol Lab Med 136, 163-71. 5 . Bishop, J.A. et al. (2010) Hum Pathol 41, 20-5. |
Western blot analysis of extracts from various cell lines using Napsin A (D5P6G) XP® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). | |
Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma (left) or squamous cell lung carcinoma (right) using Napsin A (D5P6G) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded H3255 (left) or 293 (right) cell pellets using Napsin A (D5P6G) XP® Rabbit mAb. |
