| 货号 | 5647S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | MTA1 (D40D1) XP® Rabbit mAb recognizes endogenous levels of total MTA1 protein. |
| 使用方法 | WB(1:1000) IHC-P (1:50) |
| 供应商 | CST |
| 背景 | MTA1 (metastasis associated gene 1) was identified in a differential screening of a cDNA library of metastatic and nonmetastatic adenocarcinoma cell lines (1), and was subsequently found to be an integral member of the nucleosome remodeling and deacetylation (NuRD) complex (2,3). MTA1 expression is upregulated under hypoxic conditions and found to enhance angiogenesis through stabilization of HIF-1α (4,5). MTA1 is overexpressed in a wide range of human cancers, and its expression is associated with malignancy and tumor progression (6). MTA1 is an essential downstream effector of c-Myc transformation (7). Recently, MTA1 was demonstrated to play a role in DNA damage response (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 78-82 |
Western blot analysis of extracts from MCF7 and A-204 cells using MTA1 (D40D1) XP® Rabbit mAb. 使用MTA1 (D40D1) XP® Rabbit mAb兔单抗，免疫印迹(Western blot)分析MCF7和A-204细胞中MTA1 (D40D1)的蛋白水平。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using MTA1 (D40D1) XP® Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). 使用MTA1 (D40D1) XP® Rabbit mAb，control peptide (左图)或antigen-specific peptide (右图)，免疫组化分析人源肺癌组织石蜡切片。 | |
Immunohistochemical analysis of paraffin-embedded mouse 4T1A mouse syngeneic tumor using MTA1 (D40D1) XP® Rabbit mAb. 使用MTA1 (D40D1) XP® Rabbit mAb，免疫组化分析小鼠4T1A mouse syngeneic tumor组织石蜡切片。 |
