| 货号 | 14569S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:1000) |
| 供应商 | CST |
| 背景 | Myeloperoxidase (MPO) is a peroxidase enzyme that is part of the host defense system of polymorphonuclear leukocytes (reviewed in 1). The gene for MPO was cloned independently from several laboratories (2-5). A decrease in MPO expression was noticed upon differentiation of HL-60 cells (5). MPO catalyzes the reaction of hydrogen peroxide and chloride (or other halides) to produce hypochlorous acid and other potent antimicrobial oxidants. Knockout mice of MPO are impaired in clearing select microbial infections (6). Processing of mature MPO from an initial 80-90 kDa translation product involves insertion of a heme moiety, glycosylation, and proteolytic cleavage. The mature protein is a tetramer of two heavy chains (60 kDa) and two light chains (12 kDa). It is abundantly expressed in neutrophils and monocytes and secreted during their activation. Heightened MPO levels have been associated with tissue damage and a number of pathological conditions (1). |
| 存放说明 | -20C |
| 计算分子量 | 60, 80-90 |
Immunohistochemical analysis of paraffin-embedded HL-60 (left) and HeLa (right) cell pellets using Myeloperoxidase (E1E7I) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded colon adenocarcinoma using Myeloperoxidase (E1E7I) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded non-small cell lung carcinoma using Myeloperoxidase (E1E7I) XP® Rabbit mAb. | |
Western blot analysis of extracts from various cell lines using Myeloperoxidase (E1E7I) XP® Rabbit mAb (upper) and α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower). |
