| 货号 | 8237S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IF-IC |
| 目标/特异性 | NCS1 (D12D2) XP® Rabbit mAb recognizes endogenous levels of total NCS1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) IF-IC (1:200) |
| 供应商 | CST |
| 背景 | According to affinity and function, calcium-binding proteins are separated into two classes: calcium buffers and calcium sensors. Calmodulin is a well-studied calcium sensor with well-established roles in synaptic plasticity. Neuronal calcium-sensor 1 (NCS1) is also a member of the calcium sensor family, however, its role in synaptic plasticity remains under investigation. NCS1 contains multiple EF-hand calcium-binding motifs and an amino-terminal myristoyl group (1). NCS1 has a large number of binding partners. Most of these protein interactions are calcium-dependent (e.g. dopamine D2 receptor), although some are calcium-independent (e.g. IP3 receptor) (2). In murine dentate gyrus, NCS1 promotes synaptic plasticity and rapid acquisition of spatial memory (3). |
| 存放说明 | -20C |
| 计算分子量 | 21 |
Confocal immunofluorescent analysis of COS-7 cells using NCS1 (D12D2) XP® Rabbit mAb (green). Red = Propidium Iodide/RNase (fluorescent DNA dye). 共聚焦免疫荧光分析COS-7细胞提取物，使用NCS1 (D12D2) XP® Rabbit mAb 兔单抗（绿色）进行标记。红色=Propiduim iodide/RNase (荧光DNA染料)。 | |
Western blot analysis of extracts from mouse brain, rat brain, and human cerebellum using NCS1 (D12D2) XP® Rabbit mAb. Western blot分析小鼠、大鼠大脑及人小脑提取物，使用的抗体是NCS1 (D12D2) XP® Rabbit mAb 兔单抗。 |
