| 货号 | 8637S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P/IF-IC/F |
| 使用方法 | WB(1:1000) IHC-P (1:100) F (1:200) IF-IC (1:400) |
| 供应商 | CST |
| 背景 | Ribonucleotide reductase catalyzes the rate-limiting step in the synthesis of deoxynucleotide triphosphates (dNTPs). The regulatory M1 subunit (RRM1) is present throughout the cell division cycle, but downregulated in quiescent cells (1). Research studies have demonstrated that RRM1 is involved in carcinogenesis and tumor progression, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer (2-4).核糖核苷酸还原酶能够催化脱氧核苷酸三磷酸（dNTPs）合成中的限速步骤。调节性的M1亚基（RRM1）出现在整个细胞分裂周期，但在静止期细胞中下调（1）。研究表明，RRM1参与肿瘤发生和肿瘤进展，并且其表达与非小细胞肺癌化疗抵抗相关（2-4）。 |
| 存放说明 | -20C |
| 计算分子量 | 90 |
Confocal immunofluorescent analysis of HeLa (left) and XP2YO (right) cells using RRM1 (D12F12) XP® Rabbit mAb (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).激光共聚焦免疫荧光方法检测Hela细胞（左图）和XP2YO细胞（右图），使用的抗体为RRM1 (D12F12) XP® Rabbit mAb，呈绿色。蓝色伪彩为DNA荧光染料，产品信息为DRAQ5® #4084 。 | |
Immunohistochemical analysis of paraffin-embedded human lymphoma using RRM1 (D12F12) XP®Rabbit mAb..免疫组织化学方法检测石蜡包埋人类淋巴组织，使用的抗体为RRM1 (D12F12) XP® Rabbit mAb。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using RRM1 (D12F12) XP® Rabbit mAb.免疫组织化学方法检测石蜡包埋人类肺癌组织，使用的抗体为RRM1 (D12F12) XP® Rabbit mAb。 | |
Western blot analysis of extracts from various cell lines using RRM1 (D12F12) XP® Rabbit mAb (upper) and β-Actin Antibody #4967 (lower).Western blot 方法检测不同细胞提取物，使用的抗体为RRM1 (D12F12) XP® Rabbit mAb (上图)和 β-Actin Antibody #4967 (下图)。 | |
Flow cytometric analysis of NCI-H1703 (blue) and HeLa (green) cells using RRM1 (D12F12) XP® Rabbit mAb.流式细胞术检测NCI-H1703细胞（蓝色）和Hela细胞（绿色）细胞，使用的抗体为RRM1 (D12F12) XP® Rabbit mAb。 |
