| 货号 | 98354S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H |
| 来源宿主 | Rabbit IgG |
| 应用 | W IP |
| 目标/特异性 | NMNAT1 (D7O4N) Rabbit mAb recognizes endogenous levels of total NMNAT1 protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Nicotinamide mononucleotide adenylyl transferases (NMNATs) catalyze the reversible reaction of ATP with NaMN (nicotinic acid mononucleotide) or NMN (nicotinamide mononucleotide) to produce NaAD (nicotinic acid adenine dinucleotide) or NAD (nicotinamide adenine dinucleotide). NAD is an essential cofactor or substrates for many enzymes like PARP1 and Sirt1 that regulate diverse cellular processes including oxidative reactions and transcription. NMNATs maintain NAD levels for internal homeostasis (1,2). NMNAT1 is localized to the nucleus and loss-of-function mutant in mice causes embryonic lethality (3). In humans, several different NMNAT1 mutations are associated with Leber congenital amaurosis (LCA), the most common cause of inherited childhood blindness (4-7). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 29 |
| 参考文献 | 1 . Jayaram, H.N. et al. (2011) Curr Med Chem 18, 1962-72. 2 . Ali, Y.O. et al. (2013) Trends Neurosci 36, 632-40. 3 . Conforti, L. et al. (2011) FEBS J 278, 2666-79. 4 . Chiang, P.W. et al. (2012) Nat Genet 44, 972-4. 5 . Koenekoop, R.K. et al. (2012) Nat Genet 44, 1035-9. 6 . Perrault, I. et al. (2012) Nat Genet 44, 975-7. 7 . Falk, M.J. et al. (2012) Nat Genet 44, 1040-5. |
Western blot analysis of extracts from 293T, HeLa, and SK-MEL-28 using NMNAT1 (D7O4N) Rabbit mAb (upper) or β-Tubulin (9F3) Rabbit mAb #2128 (lower). |
