| 货号 | 14623S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H M R Mk |
| 来源宿主 | Rabbit IgG |
| 应用 | W IP |
| 目标/特异性 | Neurofibromin 1 (D7R7D) Rabbit mAb recognizes endogenous levels of total neurofibromin 1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Neurofibromin is a Ras-specific GTPase activating protein (RasGAP), down-regulating Ras signaling (1). Studies have shown, that mutations in NF1 inhibit its activity, resulting in benign tumors such as neurofibromas, which may form along nerves throughout the body resulting in neurofibromatosis type 1 (NF1) (2). NF1 is one of the most common autosomal dominant diseases however it remains unclear how mutation of NF1 may lead to other features of NF1 (3). In addition, NF1 mutations occur in 5-10% of human sporadic malignancies such as glioblastomas, lung adenocarcinomas, melanomas, breast and ovarian cancers, and acute myeloid leukemias. Mutations in NF1 can cause resistance to therapies including chemotherapy and radiation therapy (3). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 320 |
| 参考文献 | 1 . Trovó-Marqui, A.B. and Tajara, E.H. (2006) Clin Genet 70, 1-13. 2 . Barker, D. et al. (1987) Science 236, 1100-2. 3 . Ratner, N. and Miller, S.J. (2015) Nat Rev Cancer 15, 290-301. |
Western blot analysis of extracts from HeLa and A204 cells using Neurofibromin 1 (D7R7D) Rabbit mAb. |
