| 货号 | 62043S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H |
| 来源宿主 | Rabbit IgG |
| 应用 | W IP |
| 目标/特异性 | TRBP2 (D7C8K) recognizes endogenous levels of total TRBP2 protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Trans-activation response (TAR) RNA binding protein (TRBP2) was initially discovered as a double stranded RNA binding protein (dsRBP) that bound TAR RNA sequences of the HIV-1 virus (1, 2). TRBP2 can bind to and inhibit the phosphorylation of protein kinase PKR, which leads to increased activation of the HIV-1 long terminal repeat (3,4). Along with PACT, TRBP2 is one of the dsRBPs in the RNA-induced silencing complex (RISC), where it plays a critical role in recruiting Ago2 to the miRNA bound by Dicer. (5-8). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 44 |
| 参考文献 | 1 . Gatignol, A. et al. (1991) Science 251, 1597-600. 2 . Kozak, C.A. et al. (1995) Genomics 25, 66-72. 3 . Park, H. et al. (1994) Proc Natl Acad Sci U S A 91, 4713-7. 4 . Daher, A. et al. (2001) J Biol Chem 276, 33899-905. 5 . Chendrimada, T.P. et al. (2005) Nature 436, 740-4. 6 . Haase, A.D. et al. (2005) EMBO Rep 6, 961-7. 7 . Maniataki, E. and Mourelatos, Z. (2005) Genes Dev 19, 2979-90. 8 . Kok, K.H. et al. (2007) J Biol Chem 282, 17649-57. |
Western blot analysis of extracts from various cell lines using TRBP2 (D7C8K) Rabbit mAb. |
