| 货号 | 55051S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H |
| 来源宿主 | Rabbit IgG |
| 应用 | IHC-P |
| 目标/特异性 | CD63 (D4I1X) Rabbit mAb (IHC Specific) recognizes endogenous levels of total CD63 protein. |
| 使用方法 | IHC-P(1:400) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | CD63 belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) (1-3). Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin enriched microdomains (TEMs) where they mediate a range of processes including adhesion, motility, membrane organization, and signal transduction (3). CD63, like other tetraspanins, is enriched in exosomes (4). It is also a component of Weibel-Palade bodies found in endothelial cells (5). Research studies demonstrate several functions of CD63 in different cell types including roles in mast cell degranulation, VEGF signaling in endothelial cells, recruitment of leukocytes to endothelial cells, and endosomal sorting during melanogenesis (6-9). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 参考文献 | 1 . Oren, R. et al. (1990) Mol Cell Biol 10, 4007-15. 2 . Levy, S. et al. (1991) J Biol Chem 266, 14597-602. 3 . Hemler, M.E. (2005) Nat Rev Mol Cell Biol 6, 801-11. 4 . Escola, J.M. et al. (1998) J Biol Chem 273, 20121-7. 5 . Vischer, U.M. and Wagner, D.D. (1993) Blood 82, 1184-91. 6 . Kraft, S. et al. (2013) J Immunol 191, 2871-8. 7 . Tugues, S. et al. (2013) J Biol Chem 288, 19060-71. 8 . Doyle, E.L. et al. (2011) Blood 118, 4265-73. 9 . van Niel, G. et al. (2011) Dev Cell 21, 708-21. |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using CD63 (D4I1X) Rabbit mAb (IHC Specific). | |
Immunohistochemical analysis of paraffin-embedded human melanoma using CD63 (D4I1X) Rabbit mAb (IHC Specific). | |
lung: | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using CD63 (D4I1X) Rabbit mAb (IHC Specific). |
