| 货号 | 45849S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H M R Mk |
| 来源宿主 | Rabbit IgG |
| 应用 | W IP |
| 目标/特异性 | SDH5 (D1S8D) Rabbit mAb recognizes endogenous levels of total SDH5 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Succinate dehydrogenase subunit 5 (SDH5, SDHAF2) is a subunit of the succinate dehydrogenase (SDH) protein complex responsible for the oxidation of succinate during the citric acid cycle. Mitochondrial SDH5 associates with the catalytic subunit of succinate dehydrogenase and is required for adding FAD cofactor to the SDH catalytic subunit (1). Mutations in the corresponding SDHAF2 gene are associated with hereditary head and neck paragangliomas, an autosomal disorder characterized by the development of tumors with increased penetrance over time (1). Additional research studies show that SDH5 is involved in the regulation of lung cancer metastasis mediated by the glycogen synthase kinase 3β and β-catenin signaling pathways (2). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 15 |
| 参考文献 | 1 . Hao, H.X. et al. (2009) Science 325, 1139-42. 2 . Liu, J. et al. (2013) J Biol Chem 288, 29965-73. |
Western blot analysis of extracts from various cell lines using SDH5 (D1S8D) Rabbit mAb. |
