| 货号 | 43584S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 目标/特异性 | APOBEC3G (D9C6Z) Rabbit mAb recognizes endogenous levels of total APOBEC3G protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | APOBEC3G, a single-strand DNA deaminase that converts deoxycytidine to deoxyuridine (1-3), is a cellular restriction factor blocking the replication of retroviruses (3). It suppresses the replication of human immunodeficiency virus-1 (HIV-1) in T-cells by being packaged into progeny virions and deaminating cytosine to uracil in the nascent minus-strand viral DNA, leading to the accumulation of mutations in the viral genome (1-4). The HIV-1 virion infectivity factor (Vif) inhibits APOBEC3G activity by preventing its incorporation into progeny virions (4,5). In addition, Vif targets APOBEC3G for ubiquitination and subsequent degradation (5). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 40 |
| 参考文献 | 1 . Sheehy, A.M. et al. (2002) Nature 418, 646-50. 2 . Mangeat, B. et al. (2003) Nature 424, 99-103. 3 . Harris, R.S. et al. (2003) Cell 113, 803-9. 4 . Mariani, R. et al. (2003) Cell 114, 21-31. 5 . Sheehy, A.M. et al. (2003) Nat Med 9, 1404-7. |
Western blot analysis of extracts from various cells using APOBEC3G (D9C6Z) Rabbit mAb. |
