| 货号 | 43239S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H M R |
| 来源宿主 | Rabbit IgG |
| 应用 | W IP |
| 目标/特异性 | EPAC2 (D3P3J) Rabbit mAb recognizes endogenous levels of total EPAC2 protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 115 |
| 参考文献 | 1 . Bos, J.L. (2006) Trends Biochem Sci 31, 680-6. 2 . Lyle, K.S. et al. (2008) Cell Signal 20, 1104-16. 3 . Branham, M.T. et al. (2009) J Biol Chem 284, 24825-39. 4 . Petersen, R.K. et al. (2008) Mol Cell Biol 28, 3804-16. 5 . Murray, A.J. and Shewan, D.A. (2008) Mol Cell Neurosci 38, 578-88. 6 . Ouyang, M. et al. (2008) Proc Natl Acad Sci USA 105, 11993-7. |
Western blot analysis of extracts from various tissues uing EPAC2 (D3P3J) Rabbit mAb (upper) or GAPDH (D16H11) XP® Rabbit mAb #5174 (lower) |
