| 货号 | 24773S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 目标/特异性 | Etk/BMX (D6J1S) Rabbit mAb recognizes endogenous levels of total Etk/BMX protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Etk, also known as BMX, is a member of the Brutons tyrosine kinase (Btk) family (1). It is expressed in a variety of hematopoietic, epithelial and endothelial cells. Etk, like other Btk family members, contains a pleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. It participates in multiple signal transduction pathways (2). Phosphorylation of Tyr566 by Src kinase is required for activation of Etk in vivo (3). In endothelial and epithelial cells, Etk is regulated by FAK through phosphorylation at Tyr40 (4). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 78 |
| 参考文献 | 1 . Tamagnone, L. et al. (1994) Oncogene 9, 3683-8. 2 . Qiu, Y. and Kung, H.J. (2000) Oncogene 19, 5651-61. 3 . Tsai, Y.T. et al. (2000) Mol Cell Biol 20, 2043-54. 4 . Chen, R. et al. (2001) Nat Cell Biol 3, 439-44. |
Western blot analysis of extracts from various cell lines using Etk/BMX (D6J1S) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower) to confirm equal loading. |
