| 货号 | 89601S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | IHC-P |
| 目标/特异性 | ICOS (D1K2T™) Rabbit mAb recognizes endogenous levels of total ICOS protein. |
| 使用方法 | IHC-P(1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | ICOS (Inducible Co-Stimulator, CD278) is a member of the CD28 family that regulates T cell activity and immune responses (1). The ICOS protein contains an extracellular IgV like domain, a transmembrane domain, and an intracellular domain with a YMFM motif (1-2). ICOS is primarily expressed on activated CD4+ and CD8+ T cells (1). Upon binding to its ligand, ICOS potentiates the T cell response to antigen through activation of the PI3K signaling pathway (2). In addition to enhancing T cell activation and proliferation, ICOS plays an important role in the regulation of T follicular helper cells (4). Research studies suggest that ICOS is a potential therapeutic target, and could serve as a prognostic biomarker for neoplastic therapy involving CTLA-4 blockade (5-7). |
| 存放说明 | -20C |
| 计算分子量 | 25-40 |
| 参考文献 | 1 . Hutloff, A. et al. (1999) Nature 397, 263-6. 2 . Coyle, A.J. et al. (2000) Immunity 13, 95-105. 3 . Fos, C. et al. (2008) J Immunol 181, 1969-77. 4 . Hutloff, A. (2015) Oncotarget 6, 21785-6. 5 . Kyi, C. and Postow, M.A. (2014) FEBS Lett 588, 368-76. 6 . Fan, X. et al. (2014) J Exp Med 211, 715-25. 7 . Ng Tang, D. et al. (2013) Cancer Immunol Res 1, 229-34. |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using ICOS (D1K2T™) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human lymphoma using ICOS (D1K2T™)Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using ICOS (D1K2T™) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human tonsil using ICOS (D1K2T™) Rabbit mAb. |
