| 货号 | 15491S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IHC-P |
| 目标/特异性 | ANP32A (D7Z5U) Rabbit mAb recognizes endogenous levels of total ANP32A protein. |
| 使用方法 | W IHC-P |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | ANP32A is the founding member of the acidic nuclear phosphoprotein 32 kDa (ANP32) family, which share two highly conserved regions: the N-terminal leucine-rich repeats (LRRs) sequence and the C-terminal acidic tail (1). ANP32A was originally purified as a potent, heat-stable protein phosphatase 2A (PP2A)-specific inhibitor, and subsequent studies suggested that it binds directly to the catalytic subunit of PP2A (2,3). ANP32A is a key component of acetyltransferase inhibitor complex that regulates chromatin remodeling and transcription (4,5). ANP32A also forms a multiunit complex with HuR that regulates RNA transport and stability (6). In addition, ANP32A is reported to play roles in apoptosis, neural differentiation and pathogenesis (7-10). |
| 存放说明 | -20C |
| 计算分子量 | 28 |
| 参考文献 | 1 . Matilla, A. and Radrizzani, M. (2005) Cerebellum 4, 7-18. 2 . Li, M. et al. (1995) Biochemistry 34, 1988-96. 3 . Li, M. et al. (1996) Biochemistry 35, 6998-7002. 4 . Seo, S.B. et al. (2002) J Biol Chem 277, 14005-10. 5 . Schneider, R. et al. (2004) J Biol Chem 279, 23859-62. 6 . Brennan, C.M. et al. (2000) J Cell Biol 151, 1-14. 7 . Jiang, X. et al. (2003) Science 299, 223-6. 8 . Chen, S. et al. (2008) J Biol Chem 283, 10513-21. 9 . Kular, R.K. et al. (2009) J Biol Chem 284, 7783-92. 10 . Cvetanovic, M. et al. (2012) Neurobiol Dis 48, 526-32. |
Western blot analysis of extracts from various cell lines using ANP32A (D7Z5U) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). | |
Immunohistochemical analysis of paraffin-embedded human serous papillary carcinoma of the ovary using ANP32A (D7Z5U) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using ANP32A (D7Z5U) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). |
