FBP1/FBPase 1 (D2T7F) Rabbit mAb
货号：
59172S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 59172S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat |
| 应用 | WB |
| 目标/特异性 | FBP1/FBPase 1 (D2T7F) Rabbit mAb recognizes endogenous levels of total FBP1/FBPase 1 protein. |
| 使用方法 | Western Blotting (1:1000)
|
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Fructose-1,6-bisphosphatase 1 (FBP1 or FBPase 1), a rate limiting enzyme in gluconeogenesis, catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate (1). Inhibition of FBP1 expression in basal-like breast cancer (BLBC) cells leads to metabolic reprogramming, including enhanced glycolysis, which leads to increased glucose uptake, biosynthesis of macromolecules, and activation of PKM2 (1). This metabolic reprogramming endows tumor cells with cancer stem cell (CSC)-like properties, thereby increasing their tumorigenicity (1). Depletion of FBP1 was also reported in more than 600 clear cell renal cell carcinoma (ccRCC) tumors, suggesting that FBP1 may inhibit ccRCC tumor progression (2). |
| 存放说明 | -20C |
| 计算分子量 | 39 |
| 参考文献 | 1 . Dong, C. et al. (2013) Cancer Cell 23, 316-31.
2 . Li, B. et al. (2014) Nature 513, 251-5.
|
参考图片Western blot analysis of extracts from MCF7 cells and various tissues using FBP1/FBPase 1 (D2T7F) Rabbit mAb. |
