| 货号 | 95343S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 应用 | WB,IP,IHC |
| 目标/特异性 | STK33 (D3S4R) Rabbit mAb recognizes endogenous levels of total STK33 protein. |
| 使用方法 | Western Blotting (1:1000) Immunoprecipitation (1:50) Immunohistochemistry (Paraffin) (1:500) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Serine/threonine protein kinase (STK33) is a 524-residue kinase that belongs to the calcium/calmodulin-dependent family of kinases (1, 2). STK33 exhibits differential expression in normal and malignant cancer tissue, including hepatocellular carcinoma (3). STK33 expression is required in the context of mutant KRAS, the most commonly mutated human oncogene, to maintain for cellular viability and proliferation (4). STK33 depletion via modulation of interacting proteins (e.g., HSP90) results in proteasome-mediated degradation of STK33 in human cancer cells, triggering apoptosis (4). |
| 存放说明 | -20C |
| 计算分子量 | 65 |
| 参考文献 | 1 . Mujica, A.O. et al. (2001) Gene 280, 175-81. 2 . Mujica, A.O. et al. (2005) FEBS J 272, 4884-98. 3 . Yang, T. et al. (2016) Gut 65, 124-33. 4 . Azoitei, N. et al. (2012) J Exp Med 209, 697-711. |
Western blot analysis of extracts from various cell lines and tissues using STK33 (D3S4R) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). | |
Immunohistochemical analysis of paraffin-embedded Daudi cell pellet (left, positive) and SK-BR-3 cell pellet (right, negative) using STK33 (D3S4R) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human ovarian carcinoma using STK33 (D3S4R) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using STK33 (D3S4R) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human testis using STK33 (D3S4R) Rabbit mAb. |
