| 货号 | 85652S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat |
| 应用 | WB |
| 目标/特异性 | Musashi (D46A8) Rabbit mAb recognizes endogenous levels of total Musashi-1 and Musashi-2 proteins. |
| 使用方法 | Western Blotting (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Musashi-1 and Musashi-2 are RNA-binding proteins which play a role in asymmetric cell division of ectodermal precursor cells by regulating the translation of target mRNA. Both family members augment Notch signaling and repress the translation of m-Numb, a protein that positively modulates differentiation of neural stem cells into neurons. Thus, Musashi contributes to the maintenance of neural stem cells (1). While Musashi-1 is frequently used as a marker for proliferating neural precursor cells, it is also expressed in epithelial stem cells including intestinal and mammary gland stem cells (2-4). |
| 存放说明 | -20C |
| 计算分子量 | 35 |
| 参考文献 | 1 . Okano, H. et al. (2005) Exp. Cell Res. 306, 349-56. 2 . Sakakibara, S. et al. (1996) Dev. Biol. 176, 230-42. 3 . Potten, C.S. et al. (2003) Differentiation 71, 28-41. 4 . Clarke, R.B. et al. (2005) Dev. Biol. 277, 443-56. |
Western blot analysis of extracts from NCCIT, SH-SY5Y, and PC-3 cells using Musashi (D46A8) Rabbit mAb. | |
Western blot analysis of extracts from neonatal mouse brain and fetal rat brain using Musashi (D46A8) Rabbit mAb. |
