| 货号 | 16743S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit IgG |
| 应用 | IHC-P, IF-F |
| 目标/特异性 | Orexin (D6G9T) Rabbit mAb recognizes endogenous levels of total orexin protein. |
| 使用方法 | IHC-P IF-F |
| 供应商 | CST |
| 灵敏度 | Endogenous (IHC-P, IF-F), Transfected (W) |
| 背景 | Orexin, also called HCRT or hypocretin, is expressed as a precursor that is processed into two biologically active neuropeptides called orexin-A (HCRT1) and orexin-B (HCRT2) (1). Orexin is expressed in the lateral and posterior hypothalamus and plays a role in feeding behavior (1). The orexin neuropeptides act by stimulating the two orexin receptors that belong to the G Protein-Coupled Receptors family (1). Orexin receptor 1 is mostly found in the hypothalamic region, while orexin receptor 2 is also found in the cerebral cortex and the nucleus accumbent (2). Orexin also plays a role in adipocyte homeostasis and is required for brown adipose tissue development, differentiation, and function (3). |
| 存放说明 | -20C |
| 计算分子量 | 16 |
| 参考文献 | 1 . Sakurai, T. et al. (1998) Cell 92, 573-85. 2 . Trivedi, P. et al. (1998) FEBS Lett 438, 71-5. 3 . Sellayah, D. et al. (2011) Cell Metab 14, 478-90. |
Confocal immunofluorescent analysis of mouse hypothalamus using Orexin (D6G9T) Rabbit mAb (green) and GFAP (GA5) Mouse mAb (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). | |
Immunohistochemical analysis of paraffin-embedded mouse hypothalamus using Orexin (D6G9T) Rabbit mAb, 5X objective (left) and 20X objective (right). | |
Immunohistochemical analysis of paraffin-embedded human brain using Orexin (D6G9T) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded rat brain using Orexin (D6G9T) Rabbit mAb. |
