| 货号 | 29798S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | Serine Racemase (D5V9Z) Rabbit mAb recognizes endogenous levels of total serine racemase protein. |
| 使用方法 | W IP |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Serine racemase, also called SRR, is an enzyme that is highly expressed in the brain and converts L-serine to D-serine (1,2). D-serine is a co-agonist of the NMDA receptor. NMDA receptor activation requires the binding of glutamate to its GluN2 subunit and the concomitant binding of either glycine or D-serine to its glycine binding site on the GluN1 subunit (3). Decreased activation of NMDA receptors is a typical feature of impaired synaptic plasticity in age-related memory deficits. Therefore, D-serine availability makes serine racemase an important therapeutic target for memory deficit associated with nonpathological aging (4). |
| 存放说明 | -20C |
| 计算分子量 | 37 |
| 参考文献 | 1 . Wolosker, H. et al. (1999) Proc Natl Acad Sci U S A 96, 13409-14. 2 . Wolosker, H. et al. (1999) Proc Natl Acad Sci U S A 96, 721-5. 3 . McBain, C.J. et al. (1989) Mol Pharmacol 36, 556-65. 4 . Billard, J.M. (2013) Eur J Neurosci 37, 1931-8. |
Western blot analysis of extracts from human cortex, mouse brain, and rat brain using Serine Racemase (D5V9Z) Rabbit mAb. | |
Immunoprecipitation of serine racemase from mouse brain extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is Serine Racemase (D5V9Z) Rabbit mAb. Western blot analysis was performed using Serine Racemase (D5V9Z) Rabbit mAb. |
