| 货号 | 39447S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | Neogenin (D7M8E) Rabbit mAb recognizes endogenous levels of total neogenin protein. |
| 使用方法 | W IP |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Neogenin is a member of the Deleted in Colorectal Cancer (DCC) receptor family. It acts as an attractive axon guidance receptor in response to netrin, and as a repellent receptor when interacting with RGMa (1,2). Neogenin also regulates adhesion and tissue organization, such as bone formation, mammary gland morphogenesis, and skeletal myofiber development, by interacting with secreted netrins (3-5). In addition, neogenin is a key regulator of adult neurogenesis by synchronizing neuroblast migration and differentiation (6). Neogenin expression has been found to be associated with cellular phenotype in cancer. In breast cancer, neogenin expression is inversely correlated with cancer grade (7), while in gastric cancer, up regulation of neogenin was found to increase cell proliferation and motility (8). |
| 存放说明 | -20C |
| 计算分子量 | 210 |
| 参考文献 | 1 . Rajagopalan, S. et al. (2004) Nat Cell Biol 6, 756-62. 2 . Wilson, B.D. et al. (2006) Science 313, 640-4. 3 . Kang, J.S. et al. (2004) J Cell Biol 167, 493-504. 4 . Srinivasan, K. et al. (2003) Dev Cell 4, 371-82. 5 . Hagihara, M. et al. (2011) J Biol Chem 286, 5157-65. 6 . OLeary, C.J. et al. (2015) Stem Cells 33, 503-14. 7 . Xing, W. et al. (2014) World J Surg Oncol 12, 352. 8 . Kim, S.J. et al. (2014) Oncotarget 5, 3386-98. |
Western blot analysis of extracts from various cell lines using Neogenin (D7M8E) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). | |
Immunoprecipitation of neogenin from Neuro-2a cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is Neogenin (D7M8E) Rabbit mAb. Western blot analysis was performed using Neogenin (D7M8E) Rabbit mAb. |
