Cyclophilin B (D1V5J) Rabbit mAb【科瑞奥博】

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Cyclophilin B (D1V5J) Rabbit mAb

货号： 43603S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	43603S
同种亚型	Rabbit IgG
反应种属	Human\Mouse\Rat\Moneky
来源宿主	Rabbit IgG
应用	WB
目标/特异性	Cyclophilin B (D1V5J) Rabbit mAb recognizes endogenous levels of total cyclophilin B protein. This antibody does not cross-react with cyclophilin A protein.
使用方法	W

性能
供应商	CST
灵敏度	Endogenous
背景	Cyclophilin B (CyPB) is an ER-localized chaperone protein belonging to the family of peptidyl-prolyl cis-trans isomerases (PPIases) (1,2). Research studies have demonstrated that CyPB associates with type I procollagen and is involved in its sorting and transport through the secretory compartment (3). Mutations in the gene encoding CyPB, PPIB, lead to aberrant biosynthesis of type I procollagen, which underlies the pathogenesis of osteogenesis imperfecta (OI), a disorder characterized by bone fragility (4-7). In additional to its role in OI, research studies demonstrate that CyPB overexpression supports the expression of multiple oncogenic drivers of glioblastoma multiforme (8).
存放说明	-20C
计算分子量	20
参考文献	1 . Price, E.R. et al. (1991) Proc Natl Acad Sci U S A 88, 1903-7. 2 . Hasel, K.W. et al. (1991) Mol Cell Biol 11, 3484-91. 3 . Smith, T. et al. (1995) J Biol Chem 270, 18323-8. 4 . Pyott, S.M. et al. (2011) Hum Mol Genet 20, 1595-609. 5 . van Dijk, F.S. et al. (2009) Am J Hum Genet 85, 521-7. 6 . Cabral, W.A. et al. (2014) PLoS Genet 10, e1004465. 7 . Choi, J.W. et al. (2009) PLoS Genet 5, e1000750. 8 . Choi, J.W. et al. (2014) Cancer Res 74, 484-96.

参考图片

Western blot analysis of extracts from various cell lines using Cyclophilin B (D1V5J) Rabbit mAb.

Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DKK-tagged full-length human cyclophilin B protein (hCyPB-Myc/DDK; +), using Cyclophilin B (D1V5J) Rabbit mAb.

Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with siRNA targeting human cyclophilin B (+), using Cyclophilin B (D1V5J) Rabbit mAb (upper) and GAPDH (D16H11) XP^® Rabbit mAb #5174 (lower).