| 货号 | 44058S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | WB |
| 目标/特异性 | LCN2 (D4M8L) Rabbit mAb recognizes endogenous levels of total LCN2 protein. |
| 使用方法 | W |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Lipocalin 2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), belongs to the lipocalin family. Proteins in this family exhibit considerable sequence diversity, but share a highly conserved structure composed of an eight-stranded antiparallel beta-barrel that encloses an internal ligand-binding site (1,2). LCN2 is considered as an iron transporter. LCN2 can bind bacterial siderophores and inhibits bacterial growth by iron depletion (3). It can also bind endogenous compounds like catechol in complex with iron (4). LCN2 was originally identified in neutrophils, and its expression was induced in many other tissues like kidney and liver in response to various pathologic states, such as infection, ischemia, and acute kidney injury. LCN2 is considered a biomarker for conditions like ischemic stroke, acute kidney injury, inflammatory and metabolic diseases (5-7). |
| 存放说明 | -20C |
| 计算分子量 | 22 |
| 参考文献 | 1 . Flower, D.R. (1996) Biochem J 318 ( Pt 1), 1-14. 2 . Grzyb, J. et al. (2006) J Plant Physiol 163, 895-915. 3 . Goetz, D.H. et al. (2002) Mol Cell 10, 1033-43. 4 . Bao, G. et al. (2010) Nat Chem Biol 6, 602-9. 5 . Haase-Fielitz, A. et al. (2014) Ann Clin Biochem 51, 335-51. 6 . Abella, V. et al. (2015) Biomarkers 20, 565-71. 7 . Hochmeister, S. et al. (2016) PLoS One 11, e0154797. |
Western blot analysis of extracts from various cell lines using LCN2 (D4M8L) Rabbit mAb (upper) or β-Tubulin (9F3) Rabbit mAb #2128 (lower). |
