| 货号 | 52632S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit IgG |
| 应用 | WB |
| 目标/特异性 | Aprataxin (D5P3C) Rabbit mAb recognizes endogenous levels of total aprataxin protein. |
| 使用方法 | W |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Aprataxin is a DNA repair protein that resolves DNA lesions (DNA adenylates) caused by abortive ligations in single-strand break repair, double-strand break repair and base excision repair (1). Aprataxin is recruited to sites of DNA damage by PARP1 (2). In the mitochondria, aprataxin and tyrosyl-DNA-phosphodiesterase 1 (TDP1) are required for repair of single strand breaks caused primarily by reactive oxygen species (ROS) (3). |
| 存放说明 | -20C |
| 计算分子量 | 40 |
| 参考文献 | 1 . Rass, U. et al. (2007) J Biol Chem 282, 9469-74. 2 . Harris, J.L. et al. (2009) Hum Mol Genet 18, 4102-17. 3 . Meagher, M. and Lightowlers, R.N. (2014) Biochimie 100, 121-4. 4 . Schellenberg, M.J. et al. (2015) Prog Biophys Mol Biol 117, 157-65. 5 . Dopeso, H. et al. (2010) Clin Cancer Res 16, 2375-82. |
Western blot analysis of extracts from various cell lines using Aprataxin (D5P3C) Rabbit mAb (upper) or β-Actin (D6F6) Rabbit mAb #8457 (lower). |
