| 货号 | 59309S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | Leupaxin (D4I3B) Rabbit mAb recognizes endogenous levels of total leupaxin protein. |
| 使用方法 | W IP |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Leupaxin is a member of the paxillin family of scaffold proteins whose functions include regulation of cell adhesion, migration and metastasis (1). Leupaxin suppresses integrin-dependent tyrosine phosphorylation of paxillin and affects the regulation of cell-matrix adhesion (2). Researchers have implicated leupaxin in the progression of human hepatocellular carcinoma through its regulation of beta-catenin-mediated transcription (3). Researchers have also shown that leupaxin regulates actin dynamics and migration of prostate cancer cells through its interaction with caldesmon (4) and down-regulation of p120-catenin (5). Studies in breast cancer implicate leupaxin in the regulation of ER-alpha transcription and invasiveness (6). |
| 存放说明 | -20C |
| 计算分子量 | 43 |
| 参考文献 | 1 . Deakin, N.O. et al. (2012) Genes Cancer 3, 362-70. 2 . Tanaka, T. et al. (2010) Cancer Sci 101, 363-8. 3 . Shi, J. et al. (2015) Tumour Biol , . 4 . Dierks, S. et al. (2015) Oncotarget 6, 13591-606. 5 . Kaulfuss, S. et al. (2009) Oncogene 28, 3971-82. 6 . Kaulfuss, S. et al. (2015) Int J Oncol 47, 106-14. |
Western blot analysis of extracts from various cell lines using Leupaxin (D4I3B) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). | |
Immuonprecipitation of leupaxin from COLO 205 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is Leupaxin (D4I3B) Rabbit mAb. Western blot analysis was performed using |
