| 货号 | 60732S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | WB |
| 目标/特异性 | NDP52 (D1E4A) Rabbit mAb recognizes endogenous levels of total NDP52 protein. |
| 使用方法 | W |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | NDP52 (CALCOCO2) is ubiquitously expressed and composed of an amino-terminal SKICH domain, followed by a coiled-coil domain, and two zinc finger domains (1). It has recently been reported to act as an autophagy receptor that binds cytosolic ubiquitinated bacteria, leading to autophagy activation and pathogen clearance (1-3). NDP52 binds ubiquitin through its zinc finger domain and simultaneously binds LC3, which directs the bacteria into autophagosomes. In addition, NDP52 interacts with Nap1 and SINTBAD to recruit TBK1 to ubiquitinated bacteria (1). |
| 存放说明 | -20C |
| 计算分子量 | 52, 60 |
| 参考文献 | 1 . Thurston, T.L. et al. (2009) Nat Immunol 10, 1215-21. 2 . Cemma, M. et al. (2011) Autophagy 7, 341-5. 3 . Mostowy, S. et al. (2011) J Biol Chem 286, 26987-95. |
Western blot analysis of extracts from various cell lines using NDP52 (D1E4A) Rabbit mAb. |
