| 货号 | 63269S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Mouse |
| 来源宿主 | Rabbit IgG |
| 应用 | IF-F |
| 目标/特异性 | VIP (D8J1V) Rabbit mAb (IF Formulated) recognizes endogenous levels of total VIP protein. It is specifically formulated for the detection of total VIP protein in fixed-frozen tissue sections using standard indirect fluorescent detection. |
| 使用方法 | IF-F |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Vasoactive intestinal polypeptide (VIP) is a neuropeptide synthesized as a precursor that is processed to an active mature peptide of 28 residues (1). VIP is produced by neurons, endocrine, and immune cells and is expressed in many tissues, in agreement with its various biological functions (2). VIP acts through activation of two receptors belonging to the G protein-coupled receptor family, VPAC1 and VPAC2 (2) and elicits several effects such as vasodilation, regulation of smooth muscle cell contractility, and blood flow in the gastrointestinal track (3,4). In addition, VIP is involved in the regulation of T cell differentiation (6), and in immunosuppression (7,8). |
| 存放说明 | -20C |
| 参考文献 | 1 . Linder, S. et al. (1987) Proc Natl Acad Sci U S A 84, 605-9. 2 . Henning, R.J. and Sawmiller, D.R. (2001) Cardiovasc Res 49, 27-37. 3 . Laburthe, M. et al. (2002) Receptors Channels 8, 137-53. 4 . Said, S.I. and Mutt, V. (1970) Science 169, 1217-8. 5 . Said, S.I. and Mutt, V. (1970) Nature 225, 863-4. 6 . Voice, J. et al. (2004) J Immunol 172, 7289-96. 7 . Bangale, Y. et al. (2003) FASEB J 17, 628-35. 8 . Andersen, O. et al. Peptides 5, 435-7. |
Confocal immunofluorescent analysis of the hypothalamic region of mouse brain using VIP (D8J1V) Rabbit mAb (IF Formulated) (green) and GFAP (GA5) Mouse mAb #3670 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). |
