PDP1 (D8Y6L) Rabbit mAb
货号：
65575S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 65575S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat\Moneky |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | PDP1 (D8Y6L) Rabbit mAb recognizes endogenous levels of total PDP1 protein. |
| 使用方法 | W IP |
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Pyruvate dehydrogenase (PDH) catalyzes decarboxylation of the glycolytic intermediate pyruvate to acetyl-CoA (1). Acetyl-CoA is further metabolized in the tricarboxylic acid (TCA) cycle to generate ATP and NADH (1). Pyruvate dehydrogenase kinase 1 (PDHK1) phosphorylates PDH to suppress its activity, while pyruvate dehydrogenase phosphatase 1 (PDP1) dephosphorylates PDH to enhance its activity (1). Phosphorylation of PDP1 at Tyr94 inhibits PDP1 and has been shown to be present in a variety of cancer cell lines and primary human leukemia cells (2). |
| 存放说明 | -20C |
| 计算分子量 | 55 |
| 参考文献 | 1 . Fan, J. et al. (2014) Mol Cell 53, 534-48.
2 . Shan, C. et al. (2014) J Biol Chem 289, 21413-22.
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参考图片Western blot analysis of extracts from various cell lines using PDP1 (D8Y6L) Rabbit mAb. |
