TSPO (D1N7Z) Rabbit mAb
货号：
70358S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 70358S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP , IF-IC |
| 目标/特异性 | TSPO (D1N7Z) Rabbit mAb recognizes endogenous levels of total TSPO protein. |
| 使用方法 | W IP IF-IC |
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Translocator protein (TSPO) is an 18 kDa mitochondrial drug- and cholesterol-transporting protein involved in steroid hormone synthesis and mitochondrial homeostasis in a variety of cell types (1,2). Originally thought to play a role exclusively in steroid synthesis in steroidogenic cells, subsequent research studies have implicated TSPO in a variety of pathologies in a broad range of tissues including progression of breast cancer, neuroinflammation, and neurological disorders (1,3-5). TSPO was first identified by its ability to bind benzodiazepines in peripheral tissues and glial cells, hence its alternate name Peripheral Benzodiazepine Receptor (PBR). |
| 存放说明 | -20C |
| 计算分子量 | 18 |
| 参考文献 | 1 . Batarseh, A. and Papadopoulos, V. (2010) Mol Cell Endocrinol 327, 1-12.
2 . Gatliff, J. and Campanella, M. (2012) Curr Mol Med 12, 356-68.
3 . Sileikyte, J. et al. (2011) J Biol Chem 286, 1046-53.
4 . Mukherjee, S. and Das, S.K. (2012) Curr Mol Med 12, 443-57.
5 . Da Pozzo, E. et al. (2012) Curr Mol Med 12, 426-42.
6 . Riond, J. et al. (1991) Eur J Biochem 195, 305-11.
7 . Veenman, L. and Gavish, M. (2012) Curr Mol Med 12, 398-412.
8 . Gatliff, J. and Campanella, M. (2012) Curr Mol Med 12, 356-68.
9 . Papadopoulos, V. et al. (1997) Steroids 62, 21-8.
10 . Batarseh, A. et al. (2012) Biochim Biophys Acta 1819, 38-56.
11 . Scarf, A.M. and Kassiou, M. (2011) J Nucl Med 52, 677-80.
12 . Rupprecht, R. et al. (2010) Nat Rev Drug Discov 9, 971-88.
13 . Venneti, S. et al. (2012) Glia , .
14 . Politis, M. et al. (2012) Front Pharmacol 3, 96.
15 . Calabresi, P.A. and Bohnen, N.I. (2012) Neurology , .
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参考图片Confocal immunofluorescent analysis of HT-1080 (left) and Hep G2 (right) cells using TSPO (D1N7Z) Rabbit mAb (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). |
Western blot analysis of extracts from various cell lines using TSPO (D1N7Z) Rabbit mAb (upper) or β-Tubulin (9F3) Rabbit mAb #2128 (lower). |
