Nav1.7 (D5L1J) Rabbit mAb
货号：
78889S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 78889S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | Nav1.7 (D5L1J) Rabbit mAb recognizes endogenous levels of total Nav1.7 protein. This antibody also detects 50, 45, and 25 kDa bands of unknown origin. |
| 使用方法 | W IP |
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Voltage gated sodium channels are composed of a large alpha subunit and auxiliary beta subunits. The alpha subunit has 4 homologous domains, with each domain containing 6 transmembrane segments. These segments function as the voltage sensor and sodium permeable pore. Upon change of membrane potential, the sodium channel is activated, which allows sodium ions to flow through (1,2). When associated with beta subunits or other accessory proteins, the alpha subunit is regulated at the level of cell surface expression, kinetics, and voltage dependence (3,4). |
| 存放说明 | -20C |
| 计算分子量 | 250 |
| 参考文献 | 1 . Catterall, W.A. (2000) Neuron 26, 13-25.
2 . Yu, F.H. and Catterall, W.A. (2003) Genome Biol 4, 207.
3 . Isom, L.L. et al. (1994) Neuron 12, 1183-94.
4 . Yu, F.H. et al. (2003) J Neurosci 23, 7577-85.
5 . Goldin, A.L. et al. (2000) Neuron 28, 365-8.
6 . Plummer, N.W. and Meisler, M.H. (1999) Genomics 57, 323-31.
7 . Goldin, A.L. (2001) Annu Rev Physiol 63, 871-94.
8 . George, A.L. et al. (1992) Ann Neurol 31, 131-7.
9 . Ou, Y. et al. (2002) Neurogastroenterol Motil 14, 477-86.
10 . Meisler, M.H. and Kearney, J.A. (2005) J Clin Invest 115, 2010-7.
11 . Minett, M.S. et al. (2012) Nat Commun 3, 791.
12 . Minett, M.S. et al. (2014) PLoS One 9, e104458.
13 . Yang, Y. et al. (2004) J Med Genet 41, 171-4.
14 . Cox, J.J. et al. (2010) Hum Mutat 31, E1670-86.
15 . Fertleman, C.R. et al. (2006) Neuron 52, 767-74.
16 . Mulley, J.C. et al. (2013) Epilepsia 54, e122-6.
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参考图片Western blot analysis of extracts from human cerebellum, mouse and rat brain using Nav1.7 (D5L1J) Rabbit mAb. |
