| 货号 | 80715S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat\Moneky |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | SHMT1 (D3B3J) recognizes endogenous levels of total SHMT1 protein. This antibody does not cross-react with SHMT2 protein. |
| 使用方法 | W |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Serine hydroxymethyltransferases 1 and 2 (SHMT1, SHMT2) are cytoplasmic and mitochondrial serine hydroxylmethyltransferases, respectively (1,2). They catalyze the conversion of serine to glycine with the transfer of β-carbon from serine to tetrahydrofolate (THF) to form 5, 10-methylene-THF (1, 2). Research studies indicate that SHMT1 hemizygosity is associated with higher risk of intestinal cancer in mice of a certain genetic background (3). Suppression of SHMT2 was shown to block cell proliferation (4). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
| 参考文献 | 1 . MacFarlane, A.J. et al. (2008) J Biol Chem 283, 25846-53. 2 . Hebbring, S.J. et al. (2012) J Neurochem 120, 881-90. 3 . Macfarlane, A.J. et al. (2011) Cancer Res 71, 2098-107. 4 . di Salvo, M.L. et al. (2013) Med Hypotheses 80, 633-6. |
Western blot analysis of extracts from various cell lines using SHMT1 (D3B3J) Rabbit mAb. |
