| 货号 | 81428S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse |
| 来源宿主 | Rabbit IgG |
| 应用 | WB |
| 目标/特异性 | LMO4 (D6V4Z) Rabbit mAb recognizes endogenous levels of total LMO4 protein. |
| 使用方法 | W |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | LMO4 is a LIM zinc-binding domain-containing protein. LMO4 cDNA was first isolated from a breast tumor cDNA library (1). This transcriptional modulator is overexpressed in several epithelial cancers such as prostate, pancreas, and breast (2-4). LMO4 exhibits pro-oncogenic activities by inducing centrosome amplification and mitotic spindle abnormalities (5). LMO4 is also expressed in the brain, in regions involved in learning and the regulation of motivated behavior. In the basolateral amygdala, LMO4 functions to negatively regulate fear learning (6). Furthermore, in the nucleus accumbens, LMO4 was found to regulate the behavioral effects of cocaine (7). |
| 存放说明 | -20C |
| 计算分子量 | 16 |
| 参考文献 | 1 . Racevskis, J. et al. (1999) Biochim Biophys Acta 1445, 148-53. 2 . Mousses, S. et al. (2002) Cancer Res 62, 1256-60. 3 . Visvader, J.E. et al. (2001) Proc Natl Acad Sci U S A 98, 14452-7. 4 . Yu, J. et al. (2008) Mol Cancer 7, 93. 5 . Montañez-Wiscovich, M.E. et al. (2010) J Pathol 222, 271-81. 6 . Maiya, R. et al. (2012) PLoS One 7, e34559. 7 . Lasek, A.W. et al. (2010) Genes Brain Behav 9, 817-24. |
Western blot analysis of extracts from various cell lines using LMO4 (D6V4Z) Rabbit mAb. |
