| 货号 | 72172S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 应用 | IHC |
| 目标/特异性 | CXCR5 (D6L3C) Rabbit mAb (IHC Specific) recognizes endogenous levels of total CXCR5 protein. |
| 使用方法 | Immunohistochemistry (Paraffin) (1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous (IHC-P) |
| 背景 | CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily (1). Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration (2). CXCR5 is expressed in both mature B cells and follicular helper T cells, and respond to CXCL13 gradient to control lymphocyte migration towards secondary lymphoid tissues (3). CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize (4). |
| 存放说明 | -20C |
| 参考文献 | 1 . Zlotnik, A. and Yoshie, O. (2000) Immunity 12, 121-7. 2 . Luster, A.D. (1998) N Engl J Med 338, 436-45. 3 . Breitfeld, D. et al. (2000) J Exp Med 192, 1545-52. 4 . Razis, E. et al. (2012) Clin Breast Cancer 12, 183-93. |
Immunohistochemical analysis of paraffin-embedded Daudi cell pellets (left, positive) and Jurkat cell pellets (right, negative) using CXCR5 (D6L3C) Rabbit mAb (IHC Specific). | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using CXCR5 (D6L3C) Rabbit mAb (IHC Specific). | |
Immunohistochemical analysis of paraffin-embedded human non-Hodgkins lymphoma using CXCR5 (D6L3C) Rabbit mAb (IHC Specific). | |
Immunohistochemical analysis of paraffin-embedded human tonsil using CXCR5 (D6L3C) Rabbit mAb (IHC Specific). |
