| 货号 | 88639S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | ROR2 (D3B6F) Rabbit mAb recognizes endogenous levels of total ROR2 protein. |
| 使用方法 | W IP |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | ROR1 and ROR2 are orphan receptor tyrosine kinases that are most closely related to MuSK and the Trk family of neurotrophin receptors. They are characterized by the presence of extracellular frizzled-like cysteine-rich domains and membrane-proximal kringle domains, both of which are assumed to mediate protein-protein interactions (1-3). The ROR family RTKs are evolutionarily conserved among Caenorhabditis elegans,Drosophila, mice, and humans (1,4). Although the functions of ROR kinases are unknown, similarities between ROR and MuSK and Trk kinases have led to speculation that ROR kinases regulate synaptic development. CAM-1, a C. elegans ortholog of the ROR family RTKs, plays several important roles in regulating cellular migration, polarity of asymmetric cell divisions, and axonal outgrowth of neurons during nematode development (4). mROR1 and mROR2 may play differential roles during the development of the nervous system (5). |
| 存放说明 | -20C |
| 计算分子量 | 135 |
| 参考文献 | 1 . Al-Shawi, R. et al. (2001) Dev Genes Evol 211, 161-71. 2 . Nomi, M. et al. (2001) Mol Cell Biol 21, 8329-35. 3 . Roszmusz, E. et al. (2001) J Biol Chem 276, 18485-90. 4 . Forrester, W.C. et al. (1999) Nature 400, 881-5. 5 . Oishi, I. et al. (1999) Genes Cells 4, 41-56. |
Western blot analysis of extracts from T-47D, SH-SY5Y and Saos-2 cell lines using ROR2 (D3B6F) Rabbit mAb. | |
Immunoprecipitation of ROR2 protein from T-47D cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is ROR2 (D3B3F) Rabbit mAb. Western blot analysis was performed using ROR2 (D3B6F) Rabbit mAb |
