| 货号 | 23846S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 应用 | WB,IP |
| 目标/特异性 | BSCL2/Seipin (D3W8C) Rabbit mAb recognizes endogenous levels of total BSCL2/Seipin protein. |
| 使用方法 | Western Blotting (1:1000) Immunoprecipitation (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Seipin/BSCL2 is a homo-oligomeric membrane protein at the endoplasmic reticulum lipid droplet junction (1). Studies have demonstrated that Seipin/BSCL2 plays an important role in adipogenesis, lipid droplet homeostasis, liposis, brain development, and spermatogenesis. However, the exact function of BSCL2/Seipin is still not clear (2-5). BSCL2/Seipin is mutated in several human diseases, including Berardinelli-Seip congenital lipodystrophy, an autosomal recessive disorder characterized by a near absence of adipose tissues, severe insulin resistance, hypertriglyceridemia, hepatic steatosis, and early onset of diabetes (6-8). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
| 参考文献 | 1 . Szymanski, K.M. et al. (2007) Proc Natl Acad Sci U S A 104, 20890-5. 2 . Liu, L. et al. (2014) Diabetes 63, 2320-31. 3 . Jiang, M. et al. (2014) Proc Natl Acad Sci U S A 111, 7054-9. 4 . Ebihara, C. et al. (2015) Hum Mol Genet 24, 4238-49. 5 . Dollet, L. et al. (2014) Biochimie 96, 166-72. 6 . Windpassinger, C. et al. (2004) Nat Genet 36, 271-6. 7 . Boutet, E. et al. (2009) Biochimie 91, 796-803. 8 . Opri, R. et al. (2016) Seizure 42, 1-6. |
Western blot analysis of extracts from 293T, U-2 OS, and HeLa cells using BSCL2/Seipin (D3W8C) Rabbit mAb (upper) or Β-actin (D6A8) Rabbit mAb #8457 (lower). |
