| 货号 | 98971S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | Ceroluplasmin (D7Q5W) Rabbit mAb recognizes endogenous levels of total Ceruloplasmin protein. |
| 使用方法 | W IP |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Ceruloplasmin is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe2+ to Fe3+, facilitating iron transport across the cell membrane (1). Mutation in Ceruloplasmin causes aceruloplasminemia, an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs, resulting in retinal degeneration, diabetes mellitus and neurological disturbances (2,3). Ceruloplasmin level in serum has been explored as a diagnostic marker for Wilson disease and ischemic heart disease (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 140 |
| 参考文献 | 1 . Pantopoulos, K. et al. (2012) Biochemistry 51, 5705-24. 2 . Miyajima, H. (2015) Neuropathology 35, 83-90. 3 . Kono, S. (2013) Int Rev Neurobiol 110, 125-51. 4 . Kelly, D. et al. (2016) Ir Med J 109, 341-3. 5 . Daybanyrova, L.V. and Shevchenko, O.P. (2015) Wiad Lek 68, 517-9. |
Western blot analysis of extracts from various cell lines using Ceruloplasmin (D7Q5W) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). |
