β-TrCP (D12C8) Rabbit mAb
货号：
11984S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11984S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | β-TrCP (D12C8) Rabbit mAb recognizes endogenous levels of total β-TrCP protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | β-transducin repeat-containing protein (β-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F-box proteins act as substrate adaptors that target proteins containing a specific phosphorylated sequence element, referred to as a phosphodegron, to the SCF E3 ubiquitin ligase complex for ubiquitination (1,2). β-TrCP targets many important proteins with diverse functions, such as p53, H-Ras, Smad4, IκBα, β-catenin, and the cell cycle checkpoint protein claspin, for ubiquitin-mediated degradation (3-5). Research studies have shown that inhibition of β-TrCP expression has a demonstrated benefit in the treatment of prostate cancer (6). |
| 存放说明 | -20C |
| 计算分子量 | 62 |
参考图片Western blot analysis of extracts from various cell lines using β-TrCP (D12C8) Rabbit mAb.Western blot检测多种细胞提取物，采用β-TrCP (D12C8) Rabbit mAb。 |
